ABSTRACT
Non-small cell lung cancer (NSCLC) accounts for about 85% of all lung cancer cases. The pathogenesis of NSCLC involves complex gene networks that include different types of non-coding RNAs, such as long non-coding RNAs (lncRNAs). The role of lncRNAs in NSCLC is gaining an increasing interest as their function is being explored in various human cancers. Recently, a new oncogenic lncRNA, LINC00152 (cytoskeleton regulator RNA (CYTOR)), has been identified in different tumor types. In NSCLC, the high expression of LINC00152 in tumor tissue and peripheral blood samples has been shown to be associated with worse prognoses of NSCLC patients. Overexpression of LINC00152 has been confirmed to promote the proliferation, invasion, and migration of NSCLC cells in vitro, as well as increase tumor growth in vivo. This review discusses the role of LINC00152 in NSCLC.
ABSTRACT
The incidence and mortality rate of cancer continues to gradually increase, although considerable research effort has been directed at elucidating the molecular mechanisms underlying biomarkers responsible for tumorigenesis. Accumulated evidence indicates that the long non-coding RNAs (lncRNAs), which are transcribed but not translated into functional proteins, contribute to cancer development. Recently, linc00152 (an lncRNA) was identified as a potent oncogene in various cancer types, and shown to be involved in cancer cell proliferation, invasiveness, and motility by sponging tumor-suppressive microRNAs acting as a competing endogenous RNA, binding to gene promoters acting as a transcriptional regulator, and binding to functional proteins. In this review, we focus on the oncogenic role of linc00152 in tumorigenesis and provided an overview of recent clinical studies on the effects of linc00152 expression in human cancers.
Subject(s)
Humans , Biomarkers , Carcinogenesis , Cell Proliferation , Incidence , MicroRNAs , Mortality , Oncogenes , RNA , RNA, Long NoncodingABSTRACT
Objective To explore the diagnostic values of long non-coding RNA (lncRNA) Linc00152, H19and ROR in esophageal cancer, and to investigate the relationship between the three and the clinicopathological features of esophageal cancer.Methods Totally 185cases of esophageal cancer diagnosed (case group) in our hospital from October 2016to December 2017, and 200healthy controls (control group) were recruited during the same period.The levels of lncRNA Linc00152, H19and ROR in the peripheral blood of subjects were detected by real-time quantitative PCR (RT-qPCR).The diagnostic values of plasma lncRNA Linc00152, H19and ROR expression in esophageal cancer and the relationship between them and the clinical and pathological features of esophageal cancer were analyzed.Results The levels of plasma lncRNA Linc00152, H19and ROR in case group were higher than those in control group, and the difference were statistically significant (P＜0.05).When combined detection with plasma lncRNA Linc00152, H19, and ROR, the area under the curve (AUC) to distinguish esophageal cancer and healthy subjects was 0.977 (95％CI:0.902-0.998, P＜0.001), and the sensitivity was 90.6％, specificity was 83.3％.In addition, the expressions of lncRNA Linc00152, H19, and ROR in plasma of patients with esophageal cancer were significantly correlated with TNM stage, histology classification and differentiation degree of tumor (P＜0.05), but were not related to gender, age, and tumor sites (P＞0.05).Multivariate analysis showed that plasma lncRNA H19and ROR levels were both independent risk factors for esophageal cancer, which is of guiding significances for predicting the risk of esophageal cancer.Conclusion LncRNA Linc00152, H19and ROR have diagnostic values for esophageal cancer, and are significantly correlated with the differentiation degree, histology classification, and TNM stage of esophageal carcinoma.Plasma lncRNA H19and ROR have potential application value in predicting the risk of esophageal cancer.
ABSTRACT
Objective The aim of this study was to explore the expression,prognosis and related function of Linc00152 in breast cancer.Methods Thirty-three cases of breast specimens were selected for RNA-Sequencing.The expression of Linc00152 was detected by qPCR in 50 pairs of breast cancer tissues and adjacent tissues.Combined with GEO and TCGA databases,the correla-tion between Linc00152 expression and the degree of malignancy and the prognosis of patients was analyzed.Cell proliferation,apopto-sis and cell migration were detected in breast cancer MDA-MB-231 cell line,gastric cancer SGC-7901 cell line and renal cell carcinoma 786-O cell line.Results Linc00152 was highly expressed in breast cancer(P<0.001),and was higher in HER2 posi-tive and triple negative breast cancer(P<0.001).In patients with high expression of Linc00152,the event-free survival and the me-tastasis-free survival were very poor(P<0.001,P<0.01).After knockdown Linc00152,the cell proliferation,migration and inva-sion were decreased and the apoptosis was increased(P<0.05).Conclusion Linc00152 has a role of promoting cancer in malignant tumors and may be a potential therapeutic target.